Fernando Santos is lacking another defensive-midfield force akin to Carvalho in his squad, although Joao Moutinho could return alongside Adrien Silva in the engine room after starting on the bench against Russian Federation.
There has been little love lost when they have met: Ronaldo once punched Godin during a Spanish Super Cup tie, but the defender got his own back in a meeting past year by elbowing the Portuguese in the head.
Midfielder Joao Moutinho could come into the side after starting on the bench against Iran.
"I think the difference is that Ronaldo has already scored four goals, he is already up there in the Golden Boot race, and Messi has done very little, and missed a penalty on top of that", said Schmeichel.
Coach Oscar Tabarez revealed he used a picture of the towering header to inspire his players in his halftime team talk in their first game in this World Cup against Egypt, where they snatched victory with Jose Gimenez's late header from a corner.
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Since his arrival at Barcelona, they have played eight LaLiga games and one Supercopa match, with a score of six goals from the Uruguayan and five from the Portuguese. Skipper Diego Godin will be in charge of shackling Ronaldo on Saturday evening. Portugal beat England in 2006; Uruguay beat Ghana in 2010.
Portugal won one and drew two of their three group matches this summer.
"They have great players like we do, but we have the best player in the world", Soares told FIFA.com, with Ronaldo set to equal ex-Germany captain Bastian Schweinsteiger's record of 38 appearances combined in World Cup finals and European Championships.
The 31-year-old had a desperate day in front of goal as Uruguay eventually ground out a 1-0 win against Egypt to kick off their campaign in Russian Federation. Meanwhile, three of Portugal's last four goals have come from outside the box. It won't just be one player marking him, it won't just be Godin.
This is only the fourth time Portugal have progressed beyond the group stages of the World Cup, but they have gone on to reach the semi-finals on two of those occasions (1966 and 2006). "We will have to work collectively to try to contain him, in order to try to limit the effect he can have".