More than 50,000 people have signed up to demonstrate in London, where they intend to fly an oversized balloon depicting the president as an angry baby in a diaper.
Melania's diary suggests that while Mr Trump is expected to avoid protests with visits outside of the capital on Friday, she will be in London for the first part of the day.
However, despite the welcome from May, many Britons remain deeply opposed to Trump's visit.
And with a giant "Trump Baby" balloon set to fly in the air over multiple demonstrations, US officials urged Americans to "keep a low profile" in the English capital.
Prior to coming to London, the president claimed a personal victory at a North Atlantic Treaty Organisation summit after telling European allies to increase spending or lose Washington's support.
An inflatable, baby version of President Donald Trump could be appearing over his golf course in Scotland this weekend.
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May welcomed the summit and said it could help address "malign activity" by Russia which Britain blames for a nerve agent attack in March on a former Russian double agent and his daughter in southwest England in March.
DONALD Trump has landed in Britain for his first official visit - and declared that the people of the United Kingdom "like me a lot".
On Thursday, Trump will travel to Blenheim Palace, the 18th-century mansion where Britain's World War Two leader Winston Churchill was born and spent most of his childhood.
"I partially won an election because of immigration", he said, also pointing to Italy's recent vote, in which Giuseppe Conte took government after campaigning on a populist anti-immigration platform.
Protests are expected against Trump, whose policies - including a travel ban on a number of predominantly Muslim countries, the detention of child migrants on the US-Mexico border and the imposition of tariffs on European Union steel and aluminium exports - have all been criticised by the UK.
"So that was the full planning that went into it - 10 pints of stout and, you know, late-night conversation."
There are also plans for protestors to gather close to the USA ambassador's residence in Regent's Park, where Trump and his wife, Melania, will stay overnight on Thursday.