The flight took off in Concord, California.
The twin-engine Cessna plane crashed in Santa Ana, and had been bound to John Wayne Airport in Orange County, said Capt.
Orange County Fire Authority Captain Steve Concialdi says the Cessna was heading to the airport when it came down and struck an empty parked auto in the lot of a Staples store.
The authorities have not yet identified those killed.
The plane is registered to the San Francisco-based real estate company Category III, according to an FAA database.
The Federal Aviation Administration said the Cessna 414 declared an emergency before crashing into a mall parking lot in the vicinity of Orange County's John Wayne Airport.
Five dead in Southern California plane crash
Although a vehicle in the lot was damaged, authorities said Sunday evening there appeared to be no injuries on the ground. The parking lot is shared by a CVS pharmacy, a Wells Fargo Bank branch, and a Michaels art-supply store among others.
The parking lot is shared by a CVS pharmacy, a Wells Fargo Bank branch, and a Michaels art-supply store among others.
Pictures also show the extensive damage to an empty vehicle after it was hit by the aircraft.
The incident reportedly occurred at around 12.30pm on Sunday.
The plane also hit a auto, but no one in that vehicle was reported injured.
The FAA arrived on the scene about 4 p.m. and the National Transportation Safety Board representatives were expected this evening, Bommarito said. A husband and wife, who survived, were pulled from the burning aircraft by an off-duty firefighter from Avalon.