The Trump administration on Monday reimposed sanctions, with further measures set to take effect in November.
President Rouhani shot back at Trump via Twitter Tuesday night, suggesting Iran would continue trading with the "EU, Russia, China & dozens of our other trading partners". Anyone doing business with Iran will NOT be doing business with the United States.
Despite not saying which consequences the USA will face in his latest statement, Iran had previously warned it could block the Strait of Hormuz, widely used by the regional states to export their oil and gas, as a comeback against the sanctions.
The national security adviser explained that the sanctions are meant to motivate the Iranian regime to "commit to give up their nuclear weapons program, their ballistic missiles, their support for terrorism".
Zarif said in his Wednesday remarks that the world was taking Iran's side in the face of U.S. acts.
China, Iran's top oil customer, buys roughly 650,000 barrels a day of crude oil from Tehran, or 7 percent of China's total crude oil imports.
"If the Americans want to keep this simplistic and impossible idea in their minds they should also know its consequences", Zarif said in an interview with the newspaper.
"For the first time in the history of the United Nations, the United States - a permanent member of the security council with veto power - is engaging in penalising nations across the entire world; not for violating a security council resolution, rather, for abiding by it", Khoshroo wrote.
He has said the deal "failed to achieve the fundamental objective of blocking all paths to an Iranian nuclear bomb" and did not address Tehran's "malign activities, including its ballistic missile programme and its support for terrorism".
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"China's lawful rights should be protected".
While cheered by Prime Minister Benjamin Netanyahu and other senior Israeli officials, the reimposition of U.S. sanctions was bemoaned by the nuclear deal's European signatories and the EU, which defended the accord and vowed to protect European firms from U.S. economic penalties.
State energy firms CNPC and Sinopec have invested billions of dollars in key Iranian oil fields such as Yadavaran and North Azadegan and have been sending oil to China.
European countries, hoping to persuade Tehran to continue to respect the deal, have promised to try to lessen the blow of sanctions and to urge their firms not to pull out.
North Korea's foreign minister Ri Yong Ho on Wednesday met with the Iranian President in Tehran on the second day of an ongoing trip to the country, Iranian state news outlets reported, with Rouhani stressing the DPRK should not place excessive trust in American commitments.
US administration officials swiftly dismissed the move.
The US now plans on adding Iranian oil and gas to the sanctions in November this year.
Trump's National Security Adviser John Bolton told Fox News that the U.S. policy "is not regime change, but we definitely want to put maximum pressure on the government".