The Duke of Cambridge's Mental Health at Work project will give employers access to training, information and resources to support their staff.
He said Lloyds would be making "substantial use" of the Mental Health at Work gateway, which he described as a "hugely impressive undertaking". "You see [so] many sad things every day that you think life is like that". He continued, "You're always dealing with despair and sadness and injury".
"The attrition builds up and you never really have the opportunity to offload anything if you're not careful".
According to a survey carried out by the mental health charity Mind, that took into account 44,000 people, half of all employees are struggling with poor mental health.
Farmer added on the dedication that not just Prince William, but all the Royals, have to mental health awareness: "My firm belief is that all of [the royals] and particularly the Duke - in this context - have done a lot of background work and really thought about this issue and their commitment is 100 per cent real".
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The survey of more than 44,000 employees also revealed that only half of those who had experienced poor mental health had talked to their employer about it, suggesting that as many as one in four United Kingdom workers is struggling in silence.
The Mental Health at Work project has been created by Heads Together, a charity headed by Prince William and his brother Prince Harry, 33.
In a speech to launch the portal which went live on Tuesday, the duke said: "If you are a business owner, a team leader, a line manager, you work in HR, or just believe in supporting the wellbeing of your colleagues - Mental Health At Work can help".
During his visit to Bristol, William met people already benefiting from the online gateway.
He said in a statement at the time: "It has been a huge privilege to fly with the East Anglia Air Ambulance". It has been a positive and wonderful experience. Now I run my own art classes for people with mental health conditions.