The German global claimed an early opening goal before further efforts from David Silva and Raheem Sterling maintained City's unbeaten start to the campaign in effortless fashion. Sterling's ball down the right flank found Bernardo, who cleverly keeps the ball on the line before cutting it back to Aguero.
City were hardly tested despite a committed effort from promoted Fulham.
There was a blow for City when Aguero limped off ahead of the beginning of their Champions League campaign, but his replacement Gabriel Jesus nearly made an immediate impact, firing off target with his first touch after being found by Silva. The Argentinian's shot was blocked but David Silva pounced, smashing the ball in off the underside of the bar after 21 minutes. Manchester City's 2018/19 third kit!
The resulting corner was cleared off to the edge of the box before it was returned back into the middle, where Sane flicks it over the keeper. However, he was adjudged to an offside position.
There could have been many more goals but while they opened up Fulham with some ease, City were unable to fully punish the London side.
In the Champions League final of 2011, they ran rings around a Manchester United team that could barely get near them for 90 minutes, with Lionel Messi at his imperious best.
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Man City host Fulham on Saturday in what will be the first match between the sides since March 2014.
The Premier League champions returned from the worldwide break in style at the Etihad Stadium.
During that time, Silva has played a key role as City have won three Premier League titles, three League Cups and an FA Cup.
The combination of Gabonese striker Pierre Aubameyang and Alexandre Lacazette up front was superb for the Gunners in this match at the Cardiff City stadium. I believe in all the guys in my squad - Sane, for example, is only 22 and he realises why he hasn't played many minutes.
But the home team restored parity in the 45th minute through Victor Camarasa who gained from a brilliant assist by Joe Benneth.