But it ended in a odd sequence that began with Garoppolo taking a hard hit from Steven Nelson along the sideline.
In the fourth quarter at Arrowhead Stadium against the Kansas City Chiefs, 49ers quarterback Jimmy Garoppolo scrambled left and turned upfield, only to be leveled by corner Steven Nelson. Chris Biderman of the Sacramento Bee reported Sherman left the locker room in a walking boot, and he'll have an MRI Monday to determine the extent of his injury.
Garoppolo's left knee buckled just before the Chiefs' cornerback delivered a shoulder-to-shoulder blow, sending Garoppolo down. He then entered the blue medical tent as C.J. On his next possession, Mahomes made one of his best plays of the season, breaking the pocket to his left before reversing field with a defender in pursuit and firing a 13-yard laser to TE Demetrius Harris in the back right corner of the end zone. San Francisco announced he was ruled out for the rest of the game.
Before the injury, Garoppolo was 20-of-30 for 251 yards with two touchdowns and no interceptions for a passer rating of 114.7. The team was 1-11 when he took over the starting job last season and promptly reeled off five straight wins. "He's a man out there, and he's a very good quarterback; and we're fortunate to have him".
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"That was his fault", Houston said of the injury that occurred in the fourth quarter of the 38-27 Chiefs victory.
Garoppolo wasn't the only Niners star to leave with an injury.
Today's game quickly went from bad to worse for the 49ers.