Depay would not be denied his goal, though, and when he used his pace to outstrip the German defence again, this time he had the beating of Neuer.
European worldwide football has a handful of truly special games and one of those is undoubtedly between the Netherlands and Germany, a rivalry which dates back to the Second World War and was played out on Saturday with the Dutch emerging as unlikely 2-0 winners.
Virgil van Dijk, Memphis Depay and Georginio Wijnaldum all scored as the home side cruised to an easy UEFA Nations League win at Amsterdam Arena.
Boss Ronald Koeman will be keen to secure all three points after a 2-1 defeat against France has left them bottom of League A Group 1.
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Unable to control his emotions during the hard chat, Michael reflected on fame and admitted he became "embarrassed by his ego". I much rather would have it have been me. "More times than people could understand, some days we wished we didn't wake up".
Since the end of their World Cup qualifying campaign in October 2017, Germany have only won one competitive match - a 2-1 World Cup win over Sweden - and gained two victories in friendlies - against Saudi Arabia and Peru.
They face a tough task in their next match on Tuesday, 16 October as they visit world champions and Nations League Group A1 leaders France. Ryan Babel's header from a corner crashed against the crossbar and Van Dijk converted the rebound.
It was also the first time that Netherlands have defeated Germany by a margin of three or more goals. And Wijnaldum added a third soon after.