The 56-year-old will appear in federal court in downtown Manhattan at noon ET, according to a letter from federal prosecutors to Judge Robert Lehrburger.
Sayoc was being transferred from federal custody in Florida and was expected to arrive in NY ahead of a Tuesday court hearing.
He faces charges for allegedly mailing more than a dozen explosive devices to prominent Democrats, CNN and critics of Republican President Donald Trump.
He appeared in court last week in Miami, where he had not yet entered a plea to charges of five federal crimes - interstate transportation of an explosive, illegal mailing of explosives, threats against former presidents and certain other persons, threatening interstate communications, and assaulting current and former federal officers.
Sayoc is accused of sending 15 devices fashioned like pipe bombs to targets including former President Barack Obama, former Secretary of State Hillary Clinton, former Vice President Joe Biden, former Central Intelligence Agency director John Brennan, billionaire investor-philanthropist Georg Soros, actor Robert De Niro, CNN and others.
Sayoc faces up to 48 years in prison if he is convicted of the five charges that were filed in NY because some of the bombs were recovered there.
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Cesar Sayoc was being transferred from federal custody in Florida.
Prosecutors told a judge that Sayoc, reportedly a rabid supporter of Trump and white nationalism, presents a flight risk and is a serious danger to the public. Kamala Harris and New Jersey Sen.
Prosecutors say the most recent crude bomb was recovered last Friday in California, addressed to liberal activist Tom Steyer.
All of the bombs were sent through the United States postal service but none exploded and no one was injured.
"While I have not lived with my son for 35 years or even heard from him in over four years, I can not express how deeply hurt, sad, shocked and confused I am to hear that my son may have caused so many people to be put in fear for their safety", Madeline Sayoc wrote in the letter, according to ABC News.
"This is not how I raised him or my children", Madeline Sayoc wrote in her letter.