Less than a week before a European Council summit, where EU leaders are due to rubber stamp the Prime Minister's deal, she is braced for fresh attacks from inside and outside her own party.
On Thursday, four ministers resigned over the draft Brexit withdrawal agreement, lawmakers hammered the document, saying it has no chance of getting through Parliament, and Brexiteers began submitting their no-confidence letters.
British media are reporting that 42 lawmakers in May's Conservative Party had given firm assurances that they had submitted no confidence letters, short of the 48 needed.. Mr Brady told BBC Radio yesterday that the threshold of 48 had not yet been reached.
She added that the next seven days "are going to be critical", and said she would be travelling back to Brussels to talk with key figures including Jean-Claude Juncker, the European Commission president, ahead of an emergency European Council summit on November 25.
When asked about the abuses hurled at her, May said: "It doesn't distract me".
At the end of a bruising week for the Prime Minister, she used an interview with the Daily Mail to tell her critics their alternative plans for Brexit would not solve the main problem - the North Ireland/Ireland border backstop arrangement.
The Foreign Minister said pro-Brexit British ministers are "not living in the real world" if they think they can renegotiate the divorce treaty agreed last week.
But because of some serious disputes within the Conservative Party, the British Parliament and the EU－and the sudden resignations of two United Kingdom ministers－one still can not say the existing Brexit deal with sail through.
In a combative piece for the Sun on Sunday, May insisted that the preliminary agreement she recently negotiated with Brussels will be "a deal that works".
Holland beat France to relegate Germany
Germany were relegated from Group A1 of the Nations League after Holland earned a surprise 2-0 win over France . "I was surprised by the France line-up and the way they played, but our match was flawless ".
The leaders of her Northern Irish allies the Democratic Unionist Party (DUP) and the opposition Labour party have both signalled that they would not back the deal in a vote.
The news came as the Government went into meltdown over leaving the European Union, with work and pensions secretary Esther McVey and Brexit secretary Dominic Raab quitting the cabinet. She would remain prime minister until the contest was over unless she opted to resign and hand over to a caretaker prime minister.
Meanwhile, Labour's Jeremy Corbyn, also speaking on Sky News, touted the possibility of a general election and claimed a second Brexit referendum was "an option for the future".
But both sides are scrambling to finalise a parallel political declaration that will set out a road-map for post-Brexit negotiations on future EU-UK ties.
"Mrs May will be invited", a diplomat said, "But even if something explosive happens and she can't come, it will go ahead regardless".
The public and political class would see her less as a beleaguered leader on her last legs and more as a dogged, determined public servant who got the job done against the odds.
"The job of a prime minister is to make tough decisions which are not always black or white. We need to be going out there and grasping opportunities", Raab told the paper.
Leadsom told the BBC on Saturday that the deal needed improving and that the 'UK can not be trapped in a permanent customs arrangement.' Many are sceptical as to whether the European Union would make significant concessions if forced back to the negotiation table.