Felicite Tomlinson passed away on Wednesday in London in the United Kingdom, according to TMZ.
She lived in the Earls Court area of West London, England.
A Metropolitan Police spokesman said: "Police were called by London Ambulance Service at 12.52pm on Wednesday, March 13 to a residential address in SW5 following reports of a female in cardiac arrest".
According to The Sun, Louis has been left "devastated and distraught" by the death of his sister, who has been praised as "loveable, caring, bright and beautiful" by "sources close to the One Direction singer". Louis was told of her death on Wednesday and has cancelled his appearance at an event scheduled for Friday.
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The UK outlet said police found no signs of drugs in the apartment.
During the program he was due to perform his new song Two of Us - a tribute to him mom Johannah Deakin, who passed away aged 43 after a battle with leukemia.
Her last social media post came on Sunday (March 10).
Felicite was well known on social media and regularly shared posts with her 1.3 million followers on Instagram. I can't imagine how hard it is right now.
Louis Tomlinson has pulled out of a planned performance at Comic Relief following his sister's death.